Featured Publications

Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population

Posted by on Jun 20, 2018 in Featured Publications, Publications | Comments Off on Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population

Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population

Middleton MA, Layeghifard M, Klingel M, Stanojevic S, Yau YCW, Zlosnik JEA, Coriati A, Ratjen FA, Tullis ED, Stephenson A, Wilcox P, Freitag A, Chilvers M, McKinney M, Lavoie A, Wang PW, Guttman DS, Waters VJ Ann Am Thorac Soc 2018 Jun; PMID: 29911888
Abstract: RATIONALE: The extent of the genetic relatedness among Pseudomonas aeruginosa isolates and its impact on clinical outcomes in the cystic fibrosis (CF) population is poorly understood. OBJECTIVES: The objectives of this study were to determine the prevalence of clonal P. aeruginosa infection in Canada and to associate P. aeruginosa...

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Diversification of Pseudomonas aeruginosa within the CF lung

Posted by on Feb 6, 2018 in Featured Publications, Publications | Comments Off on Diversification of Pseudomonas aeruginosa within the CF lung

Diversification of Pseudomonas aeruginosa within the CF lung

Clark ST, Guttman DS, Hwang DM FEMS Microbiol. Lett. 2018 Feb; PMID: 29401362
Abstract: The evolution and diversification of bacterial pathogens within human hosts represent potential barriers to the diagnosis and treatment of life-threatening infections. Tremendous genetic and phenotypic diversity is characteristic of host adaptation in strains of Pseudomonas aeruginosa that infect the airways of individuals with chronic lung diseases and prove to be extremely difficult to eradicate. In this MiniReview, we examine recent advances in understanding within-host diversity and antimicrobial...

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An extracellular network of Arabidopsis leucine-rich repeat receptor kinases

Posted by on Jan 19, 2018 in Featured Publications, Publications | Comments Off on An extracellular network of Arabidopsis leucine-rich repeat receptor kinases

An extracellular network of Arabidopsis leucine-rich repeat receptor kinases

Smakowska-Luzan E, Mott GA, Parys K, Stegmann M, Howton TC, Layeghifard M, Neuhold J, Lehner A, Kong J, Grünwald K, Weinberger N, Satbhai SB, Mayer D, Busch W, Madalinski M, Stolt-Bergner P, Provart NJ, Mukhtar MS, Zipfel C, Desveaux D, Guttman DS, Belkhadir Y Nature 2018 01;553(7688):342-346 PMID: 29320478
Abstract: The cells of multicellular organisms receive extracellular signals using surface receptors. The extracellular domains (ECDs) of cell surface receptors function as interaction platforms, and as regulatory modules of receptor activation. Understanding how interactions between ECDs...

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Association of host genome with intestinal microbial composition

Posted by on Apr 13, 2017 in Featured Publications, Publications | Comments Off on Association of host genome with intestinal microbial composition

Association of host genome with intestinal microbial composition

Turpin W, Espin-Garcia O, Xu W, Silverberg MS, Kevans D, Smith MI, Guttman DS, Griffiths A, Panaccione R, Otley A, Xu L, Shestopaloff K, Moreno-Hagelsieb G; GEM Project Research Consortium, Paterson AD, Croitoru K. Nat Genet. 2016 Nov;48(11):1413-1417. PMID: 27694960
Abstract: Intestinal microbiota is known to be important in health and disease. Its composition is influenced by both environmental and host factors. Few large-scale studies have evaluated the association between host genetic variation and the composition of microbiota. We recruited a cohort of 1,561 healthy individuals, of whom...

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Multiple Calmodulin-Binding Sites Regulate Arabidopsis CNGC12

Posted by on Aug 11, 2016 in Featured Publications, Publications | Comments Off on Multiple Calmodulin-Binding Sites Regulate Arabidopsis CNGC12

Multiple Calmodulin-Binding Sites Regulate Arabidopsis CNGC12

DeFalco TA, Marshall CB, Munro K, Kang HG, Moeder W, Ikura M, Snedden WA, Yoshioka K Plant Cell 2016 Jul;28(7):1738-51 PMID: 27335451
Abstract: Ca(2+) signaling is critical to plant immunity; however, the channels involved are poorly characterized. Cyclic nucleotide-gated channels (CNGCs) are nonspecific, Ca(2+)-permeable cation channels. Plant CNGCs are hypothesized to be negatively regulated by the Ca(2+) sensor calmodulin (CaM), and previous work has focused on a C-terminal CaM-binding domain (CaMBD) overlapping with the cyclic nucleotide binding domain of plant CNGCs. However, we show that...

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Impacts on gut microbiota during the first year of life

Posted by on Aug 11, 2016 in Featured Publications, Publications | Comments Off on Impacts on gut microbiota during the first year of life

Impacts on gut microbiota during the first year of life

Azad MB, Konya T, Persaud RR, Guttman DS, Chari RS, Field CJ, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL, BJOG 2016 May;123(6):983-993 PMID: 26412384
Abstract: OBJECTIVE: Dysbiosis of the infant gut microbiota may have long-term health consequences. This study aimed to determine the impact of maternal intrapartum antibiotic prophylaxis (IAP) on infant gut microbiota, and to explore whether breastfeeding modifies these effects. DESIGN: Prospective pregnancy cohort of Canadian infants born in 2010-2012: the Canadian Healthy Infant Longitudinal Development...

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