Publications

CAGEF has contributed to over 360 publications.

Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population

Posted by on Jun 20, 2018 in Publications | Comments Off on Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population

Middleton MA, Layeghifard M, Klingel M, Stanojevic S, Yau YCW, Zlosnik JEA, Coriati A, Ratjen FA, Tullis ED, Stephenson A, Wilcox P, Freitag A, Chilvers M, McKinney M, Lavoie A, Wang PW, Guttman DS, Waters VJ Ann Am Thorac Soc 2018 Jun; PMID: 29911888
Abstract: RATIONALE: The extent of the genetic relatedness among Pseudomonas aeruginosa isolates and its impact on clinical outcomes in the cystic fibrosis (CF) population is poorly understood. OBJECTIVES: The objectives of this study were to determine the prevalence of clonal P. aeruginosa...

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Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases

Posted by on Jun 12, 2018 in Publications | Comments Off on Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases

Gritsunov A, Peek J, Diaz Caballero J, Guttman D, Christendat D Plant J. 2018 Jun; PMID: 29890023
Abstract: Quinate is produced and used by many plants in the biosynthesis of chlorogenic acids (CGA). CGA are astringent which serves as deterrents of herbivory. They also function as antifungal agents and have potent antioxidant properties. Quinate is produced at a branch point of shikimate biosynthesis by the enzyme, quinate dehydrogenase (QDH). However, little information exists on the identity and biochemical properties of plant QDHs. In this...

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Longissimus Dorsi Muscle Transcriptomic Analysis of Yunling and Chinese Simmental Cattle Differing in Intramuscular Fat Content and Fatty Acid Composition

Posted by on Jun 11, 2018 in Publications | Comments Off on Longissimus Dorsi Muscle Transcriptomic Analysis of Yunling and Chinese Simmental Cattle Differing in Intramuscular Fat Content and Fatty Acid Composition

Zhang HM, Xia HL, Jiang HR, Mao YJ, Qu KX, Huang BZ, Gong YC, Yang ZP Genome 2018 Jun; PMID: 29883552
Abstract: Intramuscular fat (IMF) content and fatty acid (FA) composition vary significantly across beef cattle breeds, which play important roles in taste and nutritional value. However, the molecular mechanisms underlying these phenotypic differences remain unknown. The present study compared meat quality traits between Yunling cattle and Chinese Simmental cattle. Yunling cattle showed a lower IMF content and proportion of monounsaturated...

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Calmodulin as a Ca2+-Sensing Subunit of Arabidopsis Cyclic Nucleotide-Gated Channel Complexes

Posted by on Feb 21, 2018 in Publications | Comments Off on Calmodulin as a Ca2+-Sensing Subunit of Arabidopsis Cyclic Nucleotide-Gated Channel Complexes

Fischer C, DeFalco TA, Karia P, Snedden WA, Moeder W, Yoshioka K, Dietrich P Plant Cell Physiol. 2017 Jul;58(7):1208-1221 PMID: 28419310
Abstract: Ca2+ serves as a universal second messenger in eukaryotic signaling pathways, and the spatial and temporal patterns of Ca2+ concentration changes are determined by feedback and feed-forward regulation of the involved transport proteins. Cyclic nucleotide-gated channels (CNGCs) are Ca2+-permeable channels that interact with the ubiquitous Ca2+ sensor calmodulin (CaM). CNGCs interact with CaMs via...

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Using GCaMP3 to Study Ca2+ Signaling in Nicotiana Species

Posted by on Feb 21, 2018 in Publications | Comments Off on Using GCaMP3 to Study Ca2+ Signaling in Nicotiana Species

DeFalco TA, Toyota M, Phan V, Karia P, Moeder W, Gilroy S, Yoshioka K Plant Cell Physiol. 2017 Jul;58(7):1173-1184 PMID: 28482045
Abstract: Ca2+ signaling is a central component of plant biology; however, direct analysis of in vivo Ca2+ levels is experimentally challenging. In recent years, the use of genetically encoded Ca2+ indicators has revolutionized the study of plant Ca2+ signaling, although such studies have been largely restricted to the model plant Arabidopsis. We have developed stable transgenic Nicotiana benthamiana and Nicotiana...

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Diversification of Pseudomonas aeruginosa within the CF lung

Posted by on Feb 6, 2018 in Featured Publications, Publications | Comments Off on Diversification of Pseudomonas aeruginosa within the CF lung

Clark ST, Guttman DS, Hwang DM FEMS Microbiol. Lett. 2018 Feb; PMID: 29401362
Abstract: The evolution and diversification of bacterial pathogens within human hosts represent potential barriers to the diagnosis and treatment of life-threatening infections. Tremendous genetic and phenotypic diversity is characteristic of host adaptation in strains of Pseudomonas aeruginosa that infect the airways of individuals with chronic lung diseases and prove to be extremely difficult to eradicate. In this MiniReview, we examine recent advances in...

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Assembly and ecological function of the root microbiome across angiosperm plant species

Posted by on Jan 24, 2018 in Publications | Comments Off on Assembly and ecological function of the root microbiome across angiosperm plant species

Fitzpatrick CR, Copeland J, Wang PW, Guttman DS, Kotanen PM, Johnson MTJ Proc. Natl. Acad. Sci. U.S.A. 2018 Jan; PMID: 29358405
Abstract: Across plants and animals, host-associated microbial communities play fundamental roles in host nutrition, development, and immunity. The factors that shape host-microbiome interactions are poorly understood, yet essential for understanding the evolution and ecology of these symbioses. Plant roots assemble two distinct microbial compartments from surrounding soil: the rhizosphere (microbes surrounding roots)...

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An extracellular network of Arabidopsis leucine-rich repeat receptor kinases

Posted by on Jan 19, 2018 in Featured Publications, Publications | Comments Off on An extracellular network of Arabidopsis leucine-rich repeat receptor kinases

Smakowska-Luzan E, Mott GA, Parys K, Stegmann M, Howton TC, Layeghifard M, Neuhold J, Lehner A, Kong J, Grünwald K, Weinberger N, Satbhai SB, Mayer D, Busch W, Madalinski M, Stolt-Bergner P, Provart NJ, Mukhtar MS, Zipfel C, Desveaux D, Guttman DS, Belkhadir Y Nature 2018 01;553(7688):342-346 PMID: 29320478
Abstract: The cells of multicellular organisms receive extracellular signals using surface receptors. The extracellular domains (ECDs) of cell surface receptors function as interaction platforms, and as regulatory modules of receptor...

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Triphosphate Tunnel Metalloenzyme Function in Senescence Highlights a Biological Diversification of This Protein Superfamily

Posted by on Dec 5, 2017 in Publications | Comments Off on Triphosphate Tunnel Metalloenzyme Function in Senescence Highlights a Biological Diversification of This Protein Superfamily

Ung H, Karia P, Ebine K, Ueda T, Yoshioka K, Moeder W Plant Physiol. 2017 Sep;175(1):473-485 PMID: 28733390
Abstract: The triphosphate tunnel metalloenzyme (TTM) superfamily comprises a group of enzymes that hydrolyze organophosphate substrates. They exist in all domains of life, yet the biological role of most family members is unclear. Arabidopsis (Arabidopsis thaliana) encodes three TTM genes. We have previously reported that AtTTM2 displays pyrophosphatase activity and is involved in pathogen resistance. Here, we report the biochemical...

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A high-sensitivity, microtiter-based plate assay for plant MAMP-triggered immunity

Posted by on Dec 5, 2017 in Publications | Comments Off on A high-sensitivity, microtiter-based plate assay for plant MAMP-triggered immunity

Mott GA, Desveaux D, Guttman DS Mol. Plant Microbe Interact. 2017 Dec; PMID: 29199888
Abstract: The first step in the plant immune response to pathogen challenge involves the perception of conserved epitopes, called microbe-associated molecular patterns (MAMPs), by cell surface pattern recognition receptors (PRRs). Given the key roles that MAMPs and PRRs play in plant innate immunity, great effort has been expended to identify these molecules. Current methods for assaying these immune responses are often limited in their resolution and...

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