Publications

CAGEF has contributed to over 360 publications.

Calmodulin as a Ca2+-Sensing Subunit of Arabidopsis Cyclic Nucleotide-Gated Channel Complexes

Posted by on Feb 21, 2018 in Publications | Comments Off on Calmodulin as a Ca2+-Sensing Subunit of Arabidopsis Cyclic Nucleotide-Gated Channel Complexes

Fischer C, DeFalco TA, Karia P, Snedden WA, Moeder W, Yoshioka K, Dietrich P Plant Cell Physiol. 2017 Jul;58(7):1208-1221 PMID: 28419310
Abstract: Ca2+ serves as a universal second messenger in eukaryotic signaling pathways, and the spatial and temporal patterns of Ca2+ concentration changes are determined by feedback and feed-forward regulation of the involved transport proteins. Cyclic nucleotide-gated channels (CNGCs) are Ca2+-permeable channels that interact with the ubiquitous Ca2+ sensor calmodulin (CaM). CNGCs interact with CaMs via...

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Using GCaMP3 to Study Ca2+ Signaling in Nicotiana Species

Posted by on Feb 21, 2018 in Publications | Comments Off on Using GCaMP3 to Study Ca2+ Signaling in Nicotiana Species

DeFalco TA, Toyota M, Phan V, Karia P, Moeder W, Gilroy S, Yoshioka K Plant Cell Physiol. 2017 Jul;58(7):1173-1184 PMID: 28482045
Abstract: Ca2+ signaling is a central component of plant biology; however, direct analysis of in vivo Ca2+ levels is experimentally challenging. In recent years, the use of genetically encoded Ca2+ indicators has revolutionized the study of plant Ca2+ signaling, although such studies have been largely restricted to the model plant Arabidopsis. We have developed stable transgenic Nicotiana benthamiana and Nicotiana...

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Diversification of Pseudomonas aeruginosa within the CF lung

Posted by on Feb 6, 2018 in Featured Publications, Publications | Comments Off on Diversification of Pseudomonas aeruginosa within the CF lung

Clark ST, Guttman DS, Hwang DM FEMS Microbiol. Lett. 2018 Feb; PMID: 29401362
Abstract: The evolution and diversification of bacterial pathogens within human hosts represent potential barriers to the diagnosis and treatment of life-threatening infections. Tremendous genetic and phenotypic diversity is characteristic of host adaptation in strains of Pseudomonas aeruginosa that infect the airways of individuals with chronic lung diseases and prove to be extremely difficult to eradicate. In this MiniReview, we examine recent advances in...

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Assembly and ecological function of the root microbiome across angiosperm plant species

Posted by on Jan 24, 2018 in Publications | Comments Off on Assembly and ecological function of the root microbiome across angiosperm plant species

Fitzpatrick CR, Copeland J, Wang PW, Guttman DS, Kotanen PM, Johnson MTJ Proc. Natl. Acad. Sci. U.S.A. 2018 Jan; PMID: 29358405
Abstract: Across plants and animals, host-associated microbial communities play fundamental roles in host nutrition, development, and immunity. The factors that shape host-microbiome interactions are poorly understood, yet essential for understanding the evolution and ecology of these symbioses. Plant roots assemble two distinct microbial compartments from surrounding soil: the rhizosphere (microbes surrounding roots)...

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An extracellular network of Arabidopsis leucine-rich repeat receptor kinases

Posted by on Jan 19, 2018 in Featured Publications, Publications | Comments Off on An extracellular network of Arabidopsis leucine-rich repeat receptor kinases

Smakowska-Luzan E, Mott GA, Parys K, Stegmann M, Howton TC, Layeghifard M, Neuhold J, Lehner A, Kong J, Grünwald K, Weinberger N, Satbhai SB, Mayer D, Busch W, Madalinski M, Stolt-Bergner P, Provart NJ, Mukhtar MS, Zipfel C, Desveaux D, Guttman DS, Belkhadir Y Nature 2018 Jan;553(7688):342-346 PMID: 29320478
Abstract: The cells of multicellular organisms receive extracellular signals using surface receptors. The extracellular domains (ECDs) of cell surface receptors function as interaction platforms, and as regulatory modules of receptor...

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Triphosphate Tunnel Metalloenzyme Function in Senescence Highlights a Biological Diversification of This Protein Superfamily

Posted by on Dec 5, 2017 in Publications | Comments Off on Triphosphate Tunnel Metalloenzyme Function in Senescence Highlights a Biological Diversification of This Protein Superfamily

Ung H, Karia P, Ebine K, Ueda T, Yoshioka K, Moeder W Plant Physiol. 2017 Sep;175(1):473-485 PMID: 28733390
Abstract: The triphosphate tunnel metalloenzyme (TTM) superfamily comprises a group of enzymes that hydrolyze organophosphate substrates. They exist in all domains of life, yet the biological role of most family members is unclear. Arabidopsis (Arabidopsis thaliana) encodes three TTM genes. We have previously reported that AtTTM2 displays pyrophosphatase activity and is involved in pathogen resistance. Here, we report the biochemical...

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A high-sensitivity, microtiter-based plate assay for plant MAMP-triggered immunity

Posted by on Dec 5, 2017 in Publications | Comments Off on A high-sensitivity, microtiter-based plate assay for plant MAMP-triggered immunity

Mott GA, Desveaux D, Guttman DS Mol. Plant Microbe Interact. 2017 Dec; PMID: 29199888
Abstract: The first step in the plant immune response to pathogen challenge involves the perception of conserved epitopes, called microbe-associated molecular patterns (MAMPs), by cell surface pattern recognition receptors (PRRs). Given the key roles that MAMPs and PRRs play in plant innate immunity, great effort has been expended to identify these molecules. Current methods for assaying these immune responses are often limited in their resolution and...

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Oh, the places they’ll go! A survey of phytopathogen effectors and their host targets

Posted by on Dec 5, 2017 in Publications | Comments Off on Oh, the places they’ll go! A survey of phytopathogen effectors and their host targets

Khan M, Seto D, Subramaniam R, Desveaux D Plant J. 2017 Nov; PMID: 29160935
Abstract: Phytopathogens translocate effector proteins into plant cells where they sabotage the host cellular machinery to promote infection. An individual pathogen can translocate numerous distinct effectors during the infection process to target an array of host macromolecules (proteins, metabolites, DNA, etc…) and manipulate them using a variety of enzymatic activities. In this review, we have surveyed the literature for effector targets and curated them to convey...

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Identification and analysis of seven effector protein families with different adaptive and evolutionary histories in plant-associated members of the Xanthomonadaceae

Posted by on Dec 4, 2017 in Publications | Comments Off on Identification and analysis of seven effector protein families with different adaptive and evolutionary histories in plant-associated members of the Xanthomonadaceae

Assis RAB, Polloni LC, Patané JSL, Thakur S, Felestrino ÉB, Diaz-Caballero J, Digiampietri LA, Goulart LR, Almeida NF, Nascimento R, Dandekar AM, Zaini PA, Setubal JC, Guttman DS, Moreira LM Sci Rep. Published Nov 23, 2017. https://doi.org/10.1038/s41598-017-16325-1 PMID: 29170530
Abstract: The Xanthomonadaceae family consists of species of non-pathogenic and pathogenic γ-proteobacteria that infect different hosts, including humans and plants. In this study, we performed a comparative analysis using 69 fully sequenced genomes belonging to...

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Convergent selection pressures drive the evolution of rhodopsin kinetics at high altitudes via non-parallel mechanisms

Posted by on Dec 4, 2017 in Publications | Comments Off on Convergent selection pressures drive the evolution of rhodopsin kinetics at high altitudes via non-parallel mechanisms

Castiglione GM, Schott RK, Hauser FE, Chang BSW Evolution. Published Nov 16, 2017. https://doi.org/10.1111/evo.13396 PMID: 29143302
Abstract: Convergent evolution in response to similar selective pressures is a well-known phenomenon in evolutionary biology. Less well understood is how selection drives convergence in protein function, and the underlying mechanisms by which this can be achieved. Here we investigate functional convergence in the visual system of two distantly related lineages of high-altitude adapted Andean and Himalayan...

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