Publications

CAGEF has contributed to over 360 publications.

Clostridioides difficile Colonization Is Differentially Associated With Gut Microbiome Profiles by Infant Feeding Modality at 3-4 Months of Age

Posted by on Jan 13, 2020 in Publications | Comments Off on Clostridioides difficile Colonization Is Differentially Associated With Gut Microbiome Profiles by Infant Feeding Modality at 3-4 Months of Age

Drall KM, Tun HM, Morales-Lizcano NP, Konya TB, Guttman DS, Field CJ, Mandal R, Wishart DS, Becker AB, Azad MB, Lefebvre DL, Mandhane PJ, Moraes TJ, Sears MR, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL. Front Immunol. 2019 Dec 11;10:2866. doi: 10.3389/fimmu.2019.02866 PMID: 31921134
Abstract: Colonization with Clostridioides difficile occurs in up to half of infants under the age of 3 months, is strongly influenced by feeding modality and is largely asymptomatic. In spite of this, C. difficile‘s presence has been...

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Perturbations of the ZED1 pseudokinase activate plant immunity

Posted by on Jan 6, 2020 in Publications | Comments Off on Perturbations of the ZED1 pseudokinase activate plant immunity

Bastedo DP, Khan M, Martel A, Seto D, Kireeva I, Zhang J, Masud W, Millar D, Lee JY, Lee AH, Gong Y, Santos-Severino A, Guttman DS, Desveaux D. PLoS Pathog. 2019 Jul 3;15(7):e1007900. doi: 10.1371/journal.ppat.1007900 PMID: 31269090
Abstract: The Pseudomonas syringae acetyltransferase HopZ1a is delivered into host cells by the type III secretion system to promote bacterial growth. However, in the model plant host Arabidopsis thaliana, HopZ1a activity results in an effector-triggered immune response (ETI) that limits bacterial...

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Investigations into a putative role for the novel BRASSIKIN pseudokinases in compatible pollen-stigma interactions in Arabidopsis thaliana

Posted by on Dec 13, 2019 in Publications | Comments Off on Investigations into a putative role for the novel BRASSIKIN pseudokinases in compatible pollen-stigma interactions in Arabidopsis thaliana

Doucet J, Lee HK, Udugama N, Xu J, Qi B, Goring DR BMC Plant Biol. 2019 Dec 11;19(1):549. doi: 10.1186/s12870-019-2160-9. PMID:31829135
Abstract: BACKGROUND: In the Brassicaceae, the early stages of compatible pollen-stigma interactions are tightly controlled with early checkpoints regulating pollen adhesion, hydration and germination, and pollen tube entry into the stigmatic surface. However, the early signalling events in the stigma which trigger these compatible interactions remain unknown. RESULTS: A set of...

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The Receptor Kinases BAK1/SERK4 Regulate Ca2+ Channel-Mediated Cellular Homeostasis for Cell Death Containment

Posted by on Nov 6, 2019 in Publications | Comments Off on The Receptor Kinases BAK1/SERK4 Regulate Ca2+ Channel-Mediated Cellular Homeostasis for Cell Death Containment

Yu X, Xu G, Li B, de Souza Vespoli L, Liu H, Moeder W, Chen S, de Oliveira MVV, Ariádina de Souza S, Shao W, Rodrigues B, Ma Y, Chhajed S, Xue S, Berkowitz GA, Yoshioka K, He P, Shan L. Curr Biol. 2019 Oct 23. pii: S0960-9822(19)31178-9. doi: 10.1016/j.cub.2019.09.018. PMID: 31679931
Abstract: : Cell death is a vital and ubiquitous process that is tightly controlled in all organisms. However, the mechanisms underlying precise cell death control remain fragmented. As an important shared module in plant growth,...

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Comparison of Co-housing and Littermate Methods for Microbiota Standardization in Mouse Models

Posted by on Jun 3, 2019 in Publications | Comments Off on Comparison of Co-housing and Littermate Methods for Microbiota Standardization in Mouse Models

Robertson SJ, Lemire P, Maughan H, Goethel A, Turpin W, Bedrani L, Guttman DS, Croitoru K, Girardin SE, Philpott DJ Cell Rep. 2019 May 7;27(6):1910-1919.e2. doi: 10.1016/j.celrep.2019.04.023 PMID: 31067473
Abstract: : The intestinal microbiota is a fundamental factor that broadly influences physiology. Thus, studies using transgenic animals should be designed to limit the confounding effects of microbiota variation between strains. Here, we report the impact on intestinal microbiota of co-housed versus F2-generation littermates,...

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Molecular Evolution of Pseudomonas syringae Type III Secreted Effector Proteins

Posted by on Jun 3, 2019 in Publications | Comments Off on Molecular Evolution of Pseudomonas syringae Type III Secreted Effector Proteins

Dillon MM, Almeida RND, Laflamme B, Martel A, Weir BS, Desveaux D, Guttman DS Front Plant Sci. 2019 Apr 5;10:418. doi: 10.3389/fpls.2019.00418 PMID: 31024592
Abstract: Diverse Gram-negative pathogens like Pseudomonas syringae employ type III secreted effector (T3SE) proteins as primary virulence factors that combat host immunity and promote disease. T3SEs can also be recognized by plant hosts and activate an effector triggered immune (ETI) response that shifts the interaction back toward plant immunity. Consequently,...

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A Host-Pathogen Interactome Uncovers Phytopathogenic Strategies to Manipulate Plant ABA Responses

Posted by on Jun 3, 2019 in Publications | Comments Off on A Host-Pathogen Interactome Uncovers Phytopathogenic Strategies to Manipulate Plant ABA Responses

Cao FY, Khan M, Taniguchi M, Mirmiran A, Moeder W, Lumba S, Yoshioka K, Desveaux D Plant J. 2019 May 31. doi: 10.1111/tpj.14425 PMID: 31148337
Abstract: The phytopathogen Pseudomonas syringae delivers into host cells type III secreted effectors (T3SEs) that promote virulence. One virulence mechanism employed by T3SEs is to target hormone signalling pathways to perturb hormone homeostasis. The phytohormone abscisic acid (ABA) influences interactions between various phytopathogens and their plant hosts, and has been shown to be a...

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Map of physical interactions between extracellular domains of Arabidopsis leucine-rich repeat receptor kinases.

Posted by on Feb 27, 2019 in Publications | Comments Off on Map of physical interactions between extracellular domains of Arabidopsis leucine-rich repeat receptor kinases.

Mott GA, Smakowska-Luzan E, Pasha A, Parys K, Howton TC, Neuhold J, Lehner A, Grünwald K, Stolt-Bergner P, Provart NJ, Mukhtar MS, Desveaux D, Guttman DS, Belkhadir Y. Sci Data. 2019 Feb 26;6:190025. PMID: 30806640
Abstract: Plants use surface receptors to perceive information about many aspects of their local environment. These receptors physically interact to form both steady state and signalling competent complexes. The signalling events downstream of receptor activation impact both plant developmental and immune responses. Here, we present...

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Ca to the rescue – Cachannels and signaling in plant immunity

Posted by on Feb 4, 2019 in Publications | Comments Off on Ca to the rescue – Cachannels and signaling in plant immunity

Moeder W, Phan V, Yoshioka K Plant Sci. 2019 Feb;279:19-26 PMID: 30709488
Abstract: Ca is a universal second messenger in many signaling pathways in all eukaryotes including plants. Transient changes in [Ca]cyt are rapidly generated upon a diverse range of stimuli such as drought, heat, wounding, and biotic stresses (infection by pathogenic and symbiotic microorganisms), as well as developmental cues. It has been known for a while that [Ca]cyt transient signals play crucial roles to activate plant immunity and recently significant progresses...

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Penicillin binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams

Posted by on Jan 23, 2019 in Publications | Comments Off on Penicillin binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams

Clark ST, Sinha U, Zhang Y, Wang PW, Donaldson SL, Coburn B, Waters VJ, Yau YCW, Tullis DE, Guttman DS, Hwang DM Int. J. Antimicrob. Agents 2019 Jan; PMID: 30664925
Abstract: Determining the mechanisms that modulate β-lactam resistance in clinical P. aeruginosa isolates can be challenging, as the molecular profiles identified in mutation- or expression-based resistance determinant screens may not correlate with in vitro phenotypes. One of the lesser studied resistance mechanisms in P. aeruginosa is the modification of penicillin binding...

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